Publication Date: 2023/08/23
Abstract: For the simultaneous quantification of paracetamol, ambroxol hydrochloride, levocetirizine dihydrochloride, and pseudoephedrine hydrochloride in tablet dosage forms, a simple, specific, accurate, exact, and cost-effective UV-method was devised. The analysis was carried out using Cramer's rule and Gauss-Jorden elimination using UV-spectroscopy of paracetamol, ambroxol hydrochloride, levocetirizine dihydrochloride, and pseudoephedrine hydrochloride as the solvent. The absorbtion maximums for the four drugs of 243, 220, 264, and 257 nm were selected wavelenth. With a regression coefficient of 0.999, a linear response between (12ug-72ug/ml) was seen, and the percentage R.S.D. values of 0.7073, 0.6484, 1.6358, and 0.7308 fall within acceptable bounds. Method was approved in accordance with ICH recommendations.
Keywords: Paracetamol, Ambroxol Hydrochloride, Levocetirizine Dihydrochloride, Pseudoephedrine Hydrochloride, UV-Method.
DOI: https://doi.org/10.5281/zenodo.8276134
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT23JUL2125.pdf
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