Ultrasound Assisted Synthesis, Molecular Docking Studies and in Vitro Biological Activity of Azine Derivatives as Potential Antifungal Agents

Gokul Ganesan, Sreela Dasgupta, Niloufer K. Kotwal.1

1

Publication Date: 2019/07/15

Abstract: An ultrasound assisted green synthetic protocol has been developed for synthesis of substituted benzalazines using sonicator probe in aqueous medium. Several conventional synthetic methods are known for Bis-Schiff bases, they however suffer from low yields, long reaction duration, harsh conditions & use of organic solvent medium like alcohol, DCM etc.[2] The ultrasound route offered superior yields & shorter reaction times as compared to conventional methods & went smoothly in aqueous medium as against use of organic solvents. Most of the reactions went to completion with greater than 90% yields within 1 minute as indicated by TLC.

Keywords: Azine, Antifungal, Docking Studies, Lanosterol Demethylase.

DOI: No DOI Available

PDF: https://ijirst.demo4.arinfotech.co/https://ijisrt.com/wp-content/uploads/2019/05/IJISRT19AP565.pdf

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