Publication Date: 2023/07/07
Abstract: Coriandrum sativum (C. sativum) is a medicinal plant traditionally known for its antispasmodic properties. In this study, we aimed to evaluate the in-vitro antispasmodic activity of an aqueous extract of C. sativum leaves on the chicken ileum. A tissue bath model was used to determine the potency of the extract in inhibiting acetylcholine-induced contractions. The antispasmodic activity of the extract was compared with that of standard antispasmodic agents such as atropine. Phytochemical analysis was also conducted to identify the active constituents responsible for the antispasmodic activity. The results showed that the aqueous extract of C. sativum leaves exhibited significant antispasmodic activity on the chicken ileum. The extract was found to be more potent than atropine in inhibiting acetylcholine-induced contractions. The phytochemical analysis revealed the presence of alkaloids, flavonoids, and tannins, which may be responsible for the antispasmodic activity of the extract. These findings suggest that C. sativum could be a potential source of antispasmodic agents for the treatment of gastrointestinal disorders associated with increased intestinal spasms.
Keywords: Antispasmodic activity, Coriandrum sativum, Aqueous Extract.
DOI: https://doi.org/10.5281/zenodo.8123034
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT23MAY1926.pdf
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