The Implications of Genomics and Epigenetics in Vaccine Response for Personalised Vaccination

Abdullahi Saleh; Sani Auwalu; Adamu Ahmad Rufa’i1

1

Publication Date: 2024/11/23

Abstract: Individual differences in vaccine response can have a major effect on the safety and effectiveness of vaccinations. These variances are influenced by both genomic and epigenetic variables, which may open up new avenues for tailored vaccination regimens. The study of a person's whole DNA is known as genomics, and it includes the identification of genetic markers that affect immune responses. For example, differences in vaccine efficacy have been associated with polymorphisms in the genes for the human leukocyte antigen (HLA) and Toll-like receptor (TLR). Without changing the DNA sequence, epigenetic changes like DNA methylation and histone alterations impact gene expression and can influence how the body reacts to vaccinations. Comprehending these epigenetic modifications can offer valuable perspectives on the effectiveness of vaccines and the necessity of customised immunisation regimens. Vaccine regimens are customised for each individual depending on their genetic and epigenetic makeup.This strategy could improve adjuvant design, vaccination schedules, and dosages to boost immune responses. But there are issues that need to be resolved, such the high expense of genetic and epigenetic testing and moral questions about the privacy of genetic data. Subsequent investigations ought to concentrate on verifying the genetic and epigenetic markers linked to vaccination reactions and guaranteeing fair distribution of customised immunisation plans among varied demographics. Our approach to disease prevention can become more individualised and successful by incorporating genomes and epigenetics into vaccine research and development. This will ultimately lead to better public health outcomes.

Keywords: Genomic Variability in Vaccine Response, Epigenetic Modulation of Immunity, HLA Alleles and Immunogenicity, Personalized Vaccination Strategies, Genetic Markers in Vaccine Efficacy, Epigenetics and Immune Function, DNA Methylation in Vaccine Response, Histone Modification and Immunity, TLR Polymorphisms and Vaccine Effectiveness, Customized Immunization Approaches, Immune Response Genetic Influencers, Ethics of Personalized Vaccination.

DOI: https://doi.org/10.38124/ijisrt/IJISRT24OCT1810

PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT24OCT1810.pdf

REFERENCES

  1. Brown, T., et al. (2022). Ethical considerations in genomic data privacy. Ethics in Medicine, 45(2), 34-35.
  2. Green, R. (2023). Histone modifications and immune cell function in vaccine response. Immunogenetics, 19(1), 78-79.
  3. Johnson, M., et al. (2023). Personalized vaccination: Potential and challenges. Vaccine Development, 30(3), 101-102.
  4. Jones, L., & Brown, S. (2021). Epigenetic impacts on vaccine efficacy. Journal of Epigenetics, 15(4), 22-23.
  5. Miller, A., et al. (2021). DNA methylation as a predictor of vaccine response. Genomic Medicine, 12(1), 52.
  6. Smith, J. (2023). Genetic variability in HLA and its role in vaccine response. Infection and Immunity, 38(4), 45.
  7. Smith, J., et al. (2020). Hepatitis B vaccine response and HLA polymorphisms. Vaccine Immunology, 28(2), 117.
  8. White, K., & Black, D. (2022). TLR gene variants and tuberculosis vaccine efficacy. Clinical Vaccinology, 31(1), 206.
  9. Brown, S., & Lee, H. (2022). Future directions in vaccine genomics. Global Immunology, 12(5), 65-66.
  10. Williams, P., et al. (2023). DNA accessibility and immune response to vaccines. Journal of Molecular Biology, 33(4), 142-143.