Publication Date: 2023/05/15
Abstract: One of the most widespread phenolic acids in the plant world is gallic acid, also known as 3,4,5- trihydroxybenzoic acid. It is a crystalline substance that can be white or slightly yellow and finds extensive use in the food and pharmaceutical sectors. In the current study, three gallic acid compounds were created and then assessed for in silico investigations employing (PDB ID: 3VMP). When compared to common drugs like norfloxacin, it was shown that the three synthesised gallic acid derivatives with various aromatic aldehydes as schiff bases had a higher docking score and glide energy. In addition to their antioxidant properties, the newly created novel gallic acid derivatives have been shown in in silico studies to have significant potency against a variety of bacterial and fungal diseases, making them a crucial source for new antibacterial medications that focus on bacterial and fungal diseases in the future.
Keywords: Gallic Acid; Schiff Base; Aromatic Aldehyde; 3VMP; Docking Score; Glide Energy.
DOI: https://doi.org/10.5281/zenodo.7937869
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT23MAY635.pdf
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