Publication Date: 2023/06/24
Abstract: The aim of this study was to develop a colontargeted drug delivery system using a co-excipient prepared by the spray drying technique. The coexcipients used in the formulation containing blend of polymers for colonic release, the drug used in the study was Mesalamine, which is a non-steroidal antiinflammatory drug commonly used in the treatment of various inflammatory conditions. Mesalamine was directly compressed with spray dried Coexcipient. The in vitro drug release studies were carried out in simulated gastric and intestinal fluids and a pH 7.4 phosphate buffer. The release profile of the formulation showed a sustained drug release in the intestinal fluid, indicating the colon-targeted drug delivery of the formulation. Overall, the co-excipientbased formulation prepared by the spray drying technique showed promising results in terms of its physicochemical properties and colon-targeted drug delivery. This study provides a foundation for the development of novel drug delivery systems for the treatment of various inflammatory conditions affecting the colon.
Keywords: Colon targeting, pH dependent polymers, Spray drying, Coexcipient, Mesalamine.
DOI: https://doi.org/10.5281/zenodo.8077091
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT23MAY2326.pdf
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