Neuroendocrine Tumor-II as a Primary in the Central Nervous System

Hardik Sharma; Shrutikant Bhatia; Kushal Rawal; Vandana Thakur1

1

Publication Date: 2024/08/30

Abstract: Malignancies known as neuroendocrine neoplasms (NENs) have sporadic instances of developing central nervous system. It was discovered that a 36-year- old lady had a primary Neuroendocrine tumor of the brain who presented with headache, vomiting, and hearing difficulty from the left ear and was diagnosed with a left cerebellopontine angle solid mass. After subtotal excision, histology revealed a Neuroendocrine tumor-II. Adjuvant radiation was administered following a thorough search for an extracranial main tumour, which included the use of Ga-68 DOTANOC- PET-CT. This led to the identification of a primary central nervous system Neuroendocrine tumor. The patient was free of metastatic or recurrent disease at 9 months of follow-up.

Keywords: Neuroendocrine Tumor; Cerebello-Pontine Angle; Radiotherapy, Subtotal Excision.

DOI: https://doi.org/10.38124/ijisrt/IJISRT24AUG881

PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT24AUG881.pdf

REFERENCES

  1. Reed CT, Duma N, Halfdanarson T, Buckner J. Primary neuroendocrine carcinoma of the brain. BMJ Case Rep. 2019 Sep 18;12(9):e230582.
  2. Greenberg K, Thomas J, Lopez A. Primary Neuroendocrine Tumor Of The Brain: Is It Becoming More Common? Int J Med Rev Case Rep. 2020;(0):1.
  3. Audlin JR, Khullar G, Deshaies EM, Kurra S, Lavelle WF. Intradural Carcinoid Tumor Found in a Patient with No History of Cancer. World Neurosurg. 2016 Dec;96:607.e1-607.e6.
  4. Kyriakopoulos G, Mavroeidi V, Chatzellis E, Kaltsas GA, Alexandraki KI. Histopathological, immunohistochemical, genetic and molecular markers of neuroendocrine neoplasms. Ann Transl Med. 2018 Jun;6(12):252.
  5. Satturwar SP, Pantanowitz JL, Manko CD, Seigh L, Monaco SE, Pantanowitz L. Ki-67 proliferation index in neuroendocrine tumors: Can augmented reality microscopy with image analysis improve scoring? Cancer Cytopathology. 2020;128(8):535–44.
  6. Sanli Y, Garg I, Kandathil A, Kendi T, Zanetti MJB, Kuyumcu S, et al. Neuroendocrine Tumor Diagnosis and Management: 68Ga-DOTATATE PET/CT. American Journal of Roentgenology. 2018 Aug 1;211(2):267–77.
  7. Tamura R, Kuroshima Y, Nakamura Y. Primary Neuroendocrine Tumor in Brain. Case Reports in Neurological Medicine. 2014 Nov 20;2014:e295253.
  8. Vernieri C, Femia D, Pusceddu S, Capella C, Rosai J, Calareso G, et al. Primary Cerebellar Neuroendocrine Tumors: Chimeras or Real Entities A Case Report with a 6-Year Follow-Up. CRO. 2016;9(2):432–9.