Publication Date: 2023/11/28
Abstract: Skin and soft tissue infections (SSTIs) are widespread infections of the epidermis, dermis, or subcutaneous tissue. Necrotizing soft tissue infections (NSTIs) are uncommon and possibly deadly bacterial infections that cause severe skin and subcutaneous tissue necrosis. This review aims to figure out an overview of Skin and soft tissue infection and management strategies for NSTI. A literature review was performed to determine the Antibiotics recommended for the empiric treatment of NSTIs. As soon as NSTI is detected, empiric therapy of broad-spectrum antibiotics should start. The selection of the initial antibiotic is crucial. It has been demonstrated that proper use of antibiotics is associated with improved clinical outcomes and decreased morbidity and death. Rapid surgical debridement of all contaminated tissues, broad spectrum antibiotic therapy, and intensive care unit treatment of related organ failures are the cornerstone of the first urgent management of NSTIs. As a result, clindamycin, vancomycin, and piperacillin-tazobactam are frequently used as the first treatment for NSTI. In comparison to vancomycin, studies have found that linezolid is more efficient in treating SSTIs caused by MRSA or Gram- positive bacteria.
Keywords: Skin and soft tissue infection, SSTI, Necrotizing soft tissue infection, NSTI, Rare bacterial infection.
DOI: https://doi.org/10.5281/zenodo.10213053
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT23NOV546.pdf
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