Publication Date: 2023/03/01
Abstract: The aqueous extract of spent chamomile tea was used to synthesize and characterize Cu2+, and Fe3+ complexes and the antifungal activities of the complexes determined. The physiochemical parameters such as melting point, colour, percentage yield and solubility test were studied. The major Phyto-constituents present were alkaloids, Flavonoids and Tannins, which may be responsible for pharmacological activities. The extract and complexes were scanned in the wavelength ranging from 200-700nm using a UV-Vis spectrophotometer. The characteristic peaks showed a bathochromic shift in Copper (II) chloride salt. The Cu2+ and Fe3+ chamomile complexes with a Hypochromic shift in iron (iii) chloride salt. FT-IR of the crude extract and complexes contain alcohols, phenols, alkanes, amines, aromatic amine, aliphatic amine and alkyl halide in the extract and complexes with the only aromatic amine in the extract and alkyl halide in the Fe3+chamomile complex. XRF analysis determined the element content and their percentages, showing a significant change in both extract and complexes, with the Fe3+chamomile complex having the highest content of 11.7202%. The result of XRD showed the crystalline size of the complexes using the Scherrer formula as D= Kλ/β2θcos θ. The crystalline size was calculated for Cu2+ and Fe3+ complexes with a value of 73.1nm and 37.1nm, respectively. This shows that the copper complex is more crystalline. The antifungal study of the crude extract and complexes was tested on Aspergillusflavus, Aspergillusniger, Fusarium sp. and Penicilliumspp. at different concentration (mm/mg) of 12.5, 25, 50, 100 and 200. The complexes were biologically active and showed enhanced antifungal activity compared to the free ligand. The copper complex showed a better antifungal potency compared to the Iron complex. Chamomile can potentially be used as an active ingredient in the production of antifungal drugs.
Keywords: Copper complex, zinc complex, Chamomile tea, Characterizations, Anti-fungal.
DOI: https://doi.org/10.5281/zenodo.7688645
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT23FEB862_(2).pdf
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