Publication Date: 2022/06/27
Abstract: This review summarizes the advancement in liquid chromatography-mass spectrometry (LC-MS). Liquid Chromatography and Mass Spectrometer is a hyphenated technique of separation of compounds. over the past years, the combination 0f high-performance liquid chromatography and mass spectrometry (LC-MS) has been used which has a remarkable effect on drug research and development. LC-MS played a vital role in the assessment and interpretation of bioavailability and bioequivalence. This article reviews the principle of LCMS analysis using liquid chromatography and mass spectrometry. Mass spectrometry comprises 3 important parts that are ionization source, mass analyzer, and detector.
Keywords: spectrometry; bioequivalence; chromatography; mass analyzer; bioavailability.
DOI: https://doi.org/10.5281/zenodo.6760060
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT22MAY1280_(1).pdf
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