Publication Date: 2024/01/16
Abstract: A sensitive first order derivative method has been developed and validated for the determination of Loperamide hydrochloridein formulations using Methanol: HCL as a solvent. The drug showed maximum absorbance at 259 nm and amplitude measured in the range of 257 nm-275 nm. The drug obeyed linearity in the range of 400-1400 μg/mL. The present method was validated as per International Conference on Harmonization guidelines. Percent recovery for Loperamide hydrochloride was obtained in the range of 97.90 - 99.99 % , indicates accuracy and % RSD < 2, indicates precision of the method. The results showed that the proposed method is suitable, precise, accurate and rapid for determination of Loperamide hydrochloride in bulk, its tablet dosage forms.
Keywords: No Keywords Available
DOI: https://doi.org/10.5281/zenodo.10518454
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT24JAN398.pdf
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