Publication Date: 2021/09/16
Abstract: - A series of 2-(4-morpholinyl/1-piperidinyl/1- pyrrolidinyl)-4,6-diaryl pyrimidines (4a-r) have been synthesized by the condensation of 1,3-diarylpropenones with dicyandiamide (DDA) in presence of heterocyclic secondary amines such as morpholine, piperidine and pyrrolidine under conventional and nonconventional method, using inorganic supports {Fly ash supported Ba(OH)2}. The synthesis highlights a comparative study of conventional, and ultrasonication technique. The reaction time decreases from hours to minutes along with yields enhancement under ultrasound irradiation. In addition, catalytic role of Fly ash supported Ba(OH)2 was studied with different catalytic load. All the products have been characterized by IR, 1H NMR, 13C NMR and mass spectral studies. Some representative compounds were screened for their antibacterial assay and showed excellent activity.
Keywords: Pyrimidine, DDA, heterocyclic secondary amines, ultrasound irradiation, antibacterial screening.
DOI: No DOI Available
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT21AUG736.pdf
REFERENCES