Effect of Pomelo Extract on Behavioral Activity of Rats
Pritam Das1
1
Publication Date:
2024/05/15
Abstract:
Food drug interactions are again one of the
most emphasized sectors of drug interactions. The effect
of drug alters when ingested with food, beverages and
dietary supplements which interact in person. Diet and
lifestyles sometimes play a significant role on the
metabolism of drugs. In this experiment the effects Citrus
maxima fruit are studied with respect to a
Benzodiazepine moiety diazepam which includes the
Locomotory, Muscle tone and the Anti-anxiety activity
tests. Synergistic effect of C. maxima with diazepam is
being achieved that gives an idea about the usage of
diazepam in low dosing units with minimum adverse drug
reactions.
Keywords:
Food-Drug interactions, Diazepam, Pomelo, Stress, Depression.
DOI:
https://doi.org/10.38124/ijisrt/IJISRT24MAY004
PDF:
https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT24MAY004.pdf
REFERENCES
- W. A.. Ritschel, “Handbook of Basic Pharmacokinetics,” American Journal of Hospital Pharmacy, vol. 33, pp. 712, July 1976.
- P. G. Welling, “Interactions affecting Drug Absorption”, Clin. Pharmacokinet, pp.404-434 October 1984.
- F. Moreno, T.C. Hardin. M. G. Rinaldi and R. Graybill, “Itraconazole- Didanosine Excipient Interaction,” pp. 269-1508, March 1993.
- C. H. Paeng, M. Sprague and C. A. Jackevicious, “Interaction between Warfarin and Craneberry Juice,” Clin. Ther, vol. 29 pp. 1730-1735, August 2007.
- R. Bushra, N. Aslam and A. Y. Khan, “Food-Drug Interactions,” Oman. Med. J, vol. 26 pp. 77-83, March 2011.
- D. G. Bailey, G. Dresser and J. Arnold, “Grapefruit medication Interactions: a forbidden fruit or avoidable consequences?,” CMAJ, vol. 185 pp. 309-316, March 2013.
- N. Mallick and R. A. Khan, “Behavioral effects of Citrus Pardisi in rats”, Metab. Brain. Dis, vol. 31 pp. 329-335, October 2015.
- D. Wu, S. V. Otton T. Inaba, W. Kalow and E. M. Sellers, “Interactions of Amphetamine Analogs with Human Liver CYP2D6”, Biochem. Pharmacol, vol. 53 pp. 1605-1612, June 1997.
- A. Shah, S. Kumar, S. D. Simon, D. P. Singh and A. Kumar, “HIV gp 120- and methamphetamine- mediated oxidative stress induces astrocyte apoptosis via cytochrome p 450 2E1”, Cell. Death. Dis, vol. 4 pp. 850, October 2013.
- J. J. Lilja, K. T. Kivisto and P. J. Neuvonen, “Grapefruit Juice Increases Serum Concentrations of Atorvastatin and has no effect on pravastatin”, Clin. Pharmacol. Ther, vol. 66 pp. 118-127, August 1999.
- M. F. Paine, W. W. Widmer, H. L. Hart, S. N. Pusek, K. L. Beavers, A. B. Criss, S. S. Brown, B. F. Thomas and P. B. Watkins, “A furanocoumarin free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice felodipine interaction”, Am. J. Clin. Nutr, vol. 83 pp. 1097-1105,May 2006.
- D. J. Greenblatt, L. L. Moltke and J. S. Harmatz, “Time course of recovery of cytochrome P450 3A function after single doses of Grapefruit juice”, Clin. Pharmacol. Ther, vol. 74 pp. 121-129, August 2003.
- B. J. Kirby and J. D. Unadkat, “Grapefruit juice, a glass full of drug interactions”, Clin. Pharmacol. Ther, vol. 81 pp.631-633, May 2007.
- P. Vijayalakshmi and R. Radha, “An overview: Citrus maxima”, The Journal Of Phytopjharmacology, vol. 4 pp.263-267, September 2015.
- K. D. Tripathi,“ Essentials of Medical Pharmacology”, Jaypee brothers, pp.405-414, 2004.
- A. A. Walf and C. A. Frye, “The Use of The elevated Plus Maze As An Assay of Anxiety Related Behavior in Rodents”, Nat. Protoc, vol. 2 pp. 322-328, April 2013.
- U. Bhosale, R. Yegnarayanan, P. Prachi, M. Zambare and R. S. Somani, “Study of CNS Depressant and Behavioral activity of an ethanol extract of Achyranthes Aspera (Chirchita) in Mouse Model”, Annals of Neurosciences, vol. 18 pp. 44-47, April 2011.