Publication Date: 2022/12/15
Abstract: The use of polyphenols, as natural antioxidants, are gaining importance, due to their health benefits for humans, decreasing the risk of liver disease, inflammation, cardiovascular and degenerative diseases by reduction of oxidative stress and counteraction of macromolecular oxidation. Although acetaminophen is the most widely used painkilling and antipyretic, high intake or consistent use of paracetamol have been associated to a well-known contrary effect which includes nephrotoxicity, hepatotoxicity (Olaleye and Rocha, 2008). Experimental animals were randomly allocated into six groups; A, B, C, D, E, F of six animals per group (n=6). Group A was the control group and received only standard diet animal feeds and distilled water only. Group B received 4ml/kg body weight of fresh Citrullus lanatus juice only for 28days. Group C received feed and water for 28 days, and was treated only with 2g/ kg of acetaminophen on the 29th and 31th day. Group D received 4ml/kg body weight of Citrullus lanatus juice for 28 days, and was treated with single oral dose of 2g/ kg of acetaminophen, on the 29th day. Group E and F received 2ml/kg and 4ml/kg body weight of fresh Citrullus lanatus juice respectively for 28days, and was treated with 2g/ kg body weight of acetaminophen on the 29th and 31th day. At the end of the experiment, the Wistar was sacrificed and organs collected for analysis. The results of our study suggest that watermelon juice pretreatment boosted antioxidant status and offered some protection against high doses of acetaminophen induced injury in Wister rat’s testes.
Keywords: Testis, Citrulline Lunatus, Acetaminophen And Watermelon Juice
DOI: https://doi.org/10.5281/zenodo.7439854
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT22NOV410.pdf
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