Publication Date: 2024/01/08
Abstract: Polycystic ovary Syndrome (PCOS) is a heterogeneous endocrine disorder frequently used to diagnosed women attending fertility clinics in Nigeria, it is characterized by anovulation, hyperandrogenism and polycystic ovary syndrome, several factors have been associated with the pathophysiology of this disorder. The ovarian follicle contains the follicular fluid (f.f) and is the center of complex network of systemic and local signaling pathways whereby follicle grows, and oocyte acquires maturity, the Follicular fluid (f.f) contains complex mixtures of steroids, metabolites, proteins polysaccharides, small peptides, and antioxidants. A prospective cross-sectional study was conducted in four selected fertility clinics in South-South part of Nigeria, the purposive sampling technique was used to recruit participants in this study. A total of 206 women were recruited, 101(49.1%) women fulfilled the Rotterdam criteria for the diagnosis of Polycystic Ovary Syndrome (PCOS), while 105 women (50.9%) without PCOS were included as control. Immunological analysis of cytokine levels was estimated using the Enzyme linked Immunosorbent Assay (ELISA). Biochemical hyper- androgenism as described as described by the Rotterdam criteria was observed in 69(68%) of women with PCOS, There was a statistically significant increase in Follicular fluid (F.F) levels of IL-6,IL-18, and TNF- alpha (8.616±1.037,50.409±6.068 and 27.014±3.252 respectively) in the PCOS group when compared to the control group (6.777±0.815 and 48.172±5.799, 22.291±2.683), however, it was observed that IL-12 levels was lower in the PCOS group (2.144±0.258) compared to the control group (2.212±0.266).The present study was aimed to investigate Cytokines levels in women with Polycystic Ovary Syndrome(PCOS) attending Fertility clinics.
Keywords: Cytokine, Follicular Fluid, Assisted Reproductive Treatment All correspondence to:
DOI: https://doi.org/10.5281/zenodo.10469508
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT23DEC707.pdf
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