Publication Date: 2023/07/20
Abstract: Androgenetic alopecia (AGA) is a condition that affects both men and women who are genetically predisposed, resulting in a recognizable pattern of hair follicle shrinkage without scarring.The root cause of this condition can be linked to the action of the enzyme 5- alpha-reductase, responsible for converting testosterone into dihydrotestosterone (DHT), a more potent androgen. The accumulation of DHT in hair follicles ultimately leads to hair loss. The primary approach to treating AGA involves targeting the inhibition of 5- alpha-reductase. A recent trend in natural remedies involves the use of pumpkin seed for AGA treatment. In this study, the focus is on conducting virtual simulations and ADME/T (Absorption, Distribution, Metabolism, Excretion/Toxicity) analysis of active compounds found in pumpkin seed. The objective is to assess their interactions with the 5-alpha-reductase enzyme and visualize these interactions. This research aims to provide insights into the potential effectiveness of pumpkin seed as a therapeutic option for AGA, through computational evaluations of protein-ligand interactions.
Keywords: Androgenetic Alopecia, DHT, Finasteride, Pumpkin Seed, 5-Alpha Reductase.
DOI: https://doi.org/10.5281/zenodo.8262690
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT23JUL203.pdf
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