Publication Date: 2023/03/21
Abstract: Patients of oral cancer receiving Chemo-radiotherapy often develop oral mucosit is due to influence in imbalance of oral flora which colonize over it. These patients are at high risk for oral bacterial and yeast infection. OBJECTIVES: This study was aimed to evaluate the effect of radiation on oral swab and salivary bacterial and yeast flora in patients with oral cancer under chemo-radiotherapy. PATIENTS AND METHODS: Swab and saliva samples were collected before RT and post RT from each of the 77 oral cancer patients, who were advised RT and Chemotherapy. Bacterial and yeast culture and growth was done using standard techniques. RESULTS: Out of 77 patients 89.6% were male and maximum patients were from age group 61-70 years. 64% patients were tobacco chewers. Oropharynx cancer (29.8%) was found to be most common followed by tongue cancer (23.4%).A definitive decrease in Staphylococcus aureus and E. Faecium was observed in both swab and saliva samples post radiotherapy, Citrobacter was found to be significantly decreased in saliva sample post radio therapy while high prevalence of Candida colonisation in the saliva sample was observed post RT. CONCLUSION: The present study showed that changes in the oral and/or systemic environment due to cancer therapy can result in growth of many bacterial and fungal species in oral cavity that can lead to clinical bacterial/fungal infection.
Keywords: Chemo-Radiotherapy, Oral Cancer, Oral Microorganisms
DOI: https://doi.org/10.5281/zenodo.7754557
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJIRT23FEB1369_(1).pdf
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