Publication Date: 2023/11/24
Abstract: Background. Breast cancer (BC) is one of Yemeni women's leading causes of cancer mortality. In BC patients, supraclavicular radiation exposure may result in thyroid dysfunction, including hypothyroidism (HT). This case- control study aimed to evaluate the association of BC with the levels of thyroid hormones and anti-TPO Ab in Yemeni women and the influence of obesity, menopause, and treatment as effect modifiers of this association.Methods. The serum levels of FT3, TSH, FT4, anti-TPO Ab, CEA, and CA 15-3 were measured in 147 BC females (59 pretreatment and 88 post-treatment) and 70 healthy controls.Results. The results showed that BC patients had a significantly higher level of TSH than healthy controls (P = 0.048). A considerably higher level of TSH and a lower level of FT3 in post-treatment compared to pretreatment BC patients were found and associated with increased BMI and age (P < 0.05) in postmenopausal patients and decreased FT4 levels. Positive anti-TPO Ab levels were significantly higher in the BC group and post-treatment subgroup compared to the healthy control (22.4% vs. 3.3%; 22.7% vs. 3.3%, P = 0.001, respectively). HT prevalence was considerably greater in post-treatment BC patients than pretreatment BC patients (26.1% vs. 10.2%, P = 0.017).Conclusion. This study found a strong link between breast cancer, and thyroid function, and autoimmunity in Yemeni women with breast cancer, especially those who had recently been treated. A significantly higher prevalence of HT, a higher level of TSH, and a lower level of FT3 in post-treatment compared to pretreatment BC patients were associated with increasing BMI and age in post-menopausal patients. Further studies with a large sample size in the future are recommended.
Keywords: Breast Cancer, Free Triiodothyronine, Free Thyroxin, Thyroid Stimulating Hormone, Anti-Thyroid Peroxidase Antibody.
DOI: https://doi.org/10.5281/zenodo.10203410
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT23NOV206.pdf
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