Publication Date: 2023/10/03
Abstract: Researchers frequently utilize naturally occurring coumarins, which exhibit a broad range of actions like antioxidant effects, anti-inflammatory capabilities, anticancer potential, MAO-B inhibiting characteristics, and antimicrobial attributes, as a foundation for the development of innovative synthetic and semi-synthetic therapeutic agents based on coumarin. Oxygen-containing heterocyclic compounds are prevalent in both natural and synthetic substances. Coumarins are widely recognized as prominent heterocycles, characterized by the presence of a single oxygen atom within their ring structures. These compounds serve as versatile scaffolds with numerous applications, such as anti-HIV agents, pain relievers, antihistamines, insecticides, dyes, herbicides, sensitizers, fragrances, ingredients in cosmetics, and additives in the food industry. Because of their wide-ranging uses in both manufacturing and pharmaceutical industry sectors, numerous Chemists have exhibited significant interest in these substances. This review aims to emphasize various approaches for harnessing the interactions involving the coumarin moiety, which stands out as one of the most effective classes of heterocycles. Special emphasis has been placed on exploring the potential of coumarins as a vital scaffold in drug development, along with their usefulness as fluorescent markers for tasks like prodrug activation, metal sensing, and diagnostics This review brings together various research findings concerning the creation of diverse coumarin hybrids and categorizes them according to their therapeutic applications. Within this context, we conduct an examination of the current trends and pertinent subjects pertaining to coumarin and its derivative compounds.
Keywords: Coumarin, Heterocycle, Therapeutic uses.
DOI: https://doi.org/10.5281/zenodo.8402929
PDF: https://ijirst.demo4.arinfotech.co/assets/upload/files/IJISRT23SEP574.pdf
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